2-((1r,4r)-4-(4-(4-aMino-5-oxo-7,8-dihydropyriMido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid
PF-04620110
CAS: 1109276-89-2
Molecular Formula: C21H24N4O4
2-((1r,4r)-4-(4-(4-aMino-5-oxo-7,8-dihydropyriMido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid - Names and Identifiers
2-((1r,4r)-4-(4-(4-aMino-5-oxo-7,8-dihydropyriMido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid - Physico-chemical Properties
| Molecular Formula | C21H24N4O4 |
| Molar Mass | 396.44 |
| Density | 1.326 |
| Boling Point | 701.9±60.0 °C(Predicted) |
| Solubility | DMSO: soluble10mg/mL (clear solution) |
| Appearance | powder |
| Color | white to beige |
| pKa | 4.72±0.10(Predicted) |
| Storage Condition | room temp |
| Use | PF-04620110 |
| In vivo study | In rats, PF-04620110 at a dose of ≥ 0.1 mg/kg reduced plasma triglyceride levels after lipid stimulation. In rodents, inhibition of DGAT1 by PF-04620110 results in an enrichment of polyunsaturated fatty acids including triglyceride lipids. |
2-((1r,4r)-4-(4-(4-aMino-5-oxo-7,8-dihydropyriMido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
2-((1r,4r)-4-(4-(4-aMino-5-oxo-7,8-dihydropyriMido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.522 ml | 12.612 ml | 25.224 ml |
| 5 mM | 0.504 ml | 2.522 ml | 5.045 ml |
| 10 mM | 0.252 ml | 1.261 ml | 2.522 ml |
| 5 mM | 0.05 ml | 0.252 ml | 0.504 ml |
Last Update：2024-01-02 23:10:35
2-((1r,4r)-4-(4-(4-aMino-5-oxo-7,8-dihydropyriMido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid - Reference Information
| biological activity | PF-04620110 is an orally active, selective Diglyceride Acyltransferase -1(DGAT1) inhibitor, IC50 19 nM. PF-04620110 is an orally potent, selective Diglyceride Acyltransferase -1(DGAT1) inhibitor with an IC50 of 19 nM. |
| Target | Value |
| DGAT1 | 19 nM |
Last Update：2024-04-10 22:29:15
![2-((1r,4r)-4-(4-(4-aMino-5-oxo-7,8-dihydropyriMido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid](http://res.chembk.com/assets/str/2d/1/11/1109276-89-2.png)
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Product Name: PF-04620110 Request for quotation
CAS: 1109276-89-2
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Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 1109276-89-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: PF-04620110 Visit Supplier Webpage Request for quotation
CAS: 1109276-89-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 1109276-89-2
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Mobile: 18021002903
QQ: 3008007409
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